Development Shapes a Consistent Inbreeding Effect in Mouse Crania of Different Line Crosses.

ABSTRACT: Development translates genetic variation into a multivariate pattern of phenotypic variation, distributing it among traits in a nonuniform manner. As developmental processes are largely shared within species, this suggests that heritable phenotypic variation will be patterned similarly, in spite of the different segregating alleles. To investigate developmental effect on the variational pattern in the shape of the mouse skull across genetically differentiated lines, we employed the full set of reciprocal crosses (a.k.a. diallel) between eight inbred mouse strains of the Collaborative Cross Project. We used geometric morphometrics and multivariate analysis to capture cranial size and shape changes in 8 parentals and their 54 F1 crosses. The high heterozygosity generated in the F1 crosses al

SUBMITTER: Pavlicev M 

PROVIDER: S-EPMC5266702 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature