A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype-genotype association study.

ABSTRACT:

Background

Western Cambodia is the epicentre of Plasmodium falciparum multidrug resistance and is facing high rates of dihydroartemisinin-piperaquine treatment failures. Genetic tools to detect the multidrug-resistant parasites are needed. Artemisinin resistance can be tracked using the K13 molecular marker, but no marker exists for piperaquine resistance. We aimed to identify genetic markers of piperaquine resistance and study their association with dihydroartemisinin-piperaquine treatment failures.

Methods

We obtained blood samples from Cambodian patients infected with P falciparum and treated with dihydroartemisinin-piperaquine. Patients were followed up for 42 days during the years 2009-15. We established in-vitro and ex-vivo susceptibility profiles for a subset using pi

SUBMITTER: Witkowski B 

PROVIDER: S-EPMC5266792 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature