Right Hemisphere Remapping of Naming Functions Depends on Lesion Size and Location in Poststroke Aphasia.

ABSTRACT: The study of language network plasticity following left hemisphere stroke is foundational to the understanding of aphasia recovery and neural plasticity in general. Damage in different language nodes may influence whether local plasticity is possible and whether right hemisphere recruitment is beneficial. However, the relationships of both lesion size and location to patterns of remapping are poorly understood. In the context of a picture naming fMRI task, we tested whether lesion size and location relate to activity in surviving left hemisphere language nodes, as well as homotopic activity in the right hemisphere during covert name retrieval and overt name production. We found that lesion size was positively associated with greater right hemisphere activity during both phases of naming, a

SUBMITTER: Skipper-Kallal LM 

PROVIDER: S-EPMC5266856 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature