Hyponatremia is a marker of disease severity in HIV-infected patients: a retrospective cohort study.

ABSTRACT:

Background

Hyponatremia is a frequent electrolyte disorder in HIV-infected patients with a prevalence of up to 56% in the pre-cART era. Several studies have demonstrated that patients with hyponatremia are at an increased risk of death. We aimed to investigate the prevalence of hyponatremia in the recent cART-era and evaluate its association with mortality.

Methods

Single-center retrospective cohort study. A total of 1196 newly diagnosed and cART-naïve HIV patients followed at the AIDS Reference Center, St Pierre University Hospital in Brussels, Belgium, between 1 January 1998 and 31 December 2013 were included. Hyponatremia was defined as a baseline natremia lower than 135 mmol/l. The outcome of interest was the occurrence of death.

Results

In this study 177 (14.8%)

SUBMITTER: Braconnier P 

PROVIDER: S-EPMC5267411 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature