Overgrazing induces alterations in the hepatic proteome of sheep (Ovis aries): an iTRAQ-based quantitative proteomic analysis.

ABSTRACT:

Background

The degradation of the steppe of Inner Mongolia, due to overgrazing, has resulted in ecosystem damage as well as extensive reductions in sheep production. The growth performance of sheep is greatly reduced because of overgrazing, which triggers massive economic losses every year. The liver is an essential organ that has very important roles in multiple functions, such as nutrient metabolism, immunity and others, which are closely related to animal growth. However, to our knowledge, no detailed studies have evaluated hepatic metabolism adaption in sheep due to overgrazing. The molecular mechanisms that underlie these effects remain unclear.

Methods

In the present study, our group applied isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitativ

SUBMITTER: Ren W 

PROVIDER: S-EPMC5267464 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature