Performance of toxicity probability interval based designs in contrast to the continual reassessment method.

ABSTRACT: Toxicity probability interval designs have received increasing attention as a dose-finding method in recent years. In this study, we compared the two-stage, likelihood-based continual reassessment method (CRM), modified toxicity probability interval (mTPI), and the Bayesian optimal interval design (BOIN) in order to evaluate each method's performance in dose selection for phase I trials. We use several summary measures to compare the performance of these methods, including percentage of correct selection (PCS) of the true maximum tolerable dose (MTD), allocation of patients to doses at and around the true MTD, and an accuracy index. This index is an efficiency measure that describes the entire distribution of MTD selection and patient allocation by taking into account the distance between

SUBMITTER: Horton BJ 

PROVIDER: S-EPMC5267938 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature