Maternal Pre-Pregnancy Obesity Is Associated with Altered Placental Transcriptome.

ABSTRACT: Maternal obesity has a major impact on pregnancy outcomes. There is growing evidence that maternal obesity has a negative influence on placental development and function, thereby adversely influencing offspring programming and health outcomes. However, the molecular mechanisms underlying these processes are poorly understood. We analysed ten term placenta's whole transcriptomes in obese (n = 5) and normal weight women (n = 5), using the Affymetrix microarray platform. Analyses of expression data were carried out using non-parametric methods. Hierarchical clustering and principal component analysis showed a clear distinction in placental transcriptome between obese and normal weight women. We identified 72 differentially regulated genes, with most being down-regulated in obesity (n = 61). F

SUBMITTER: Altmae S 

PROVIDER: S-EPMC5268451 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature