Activity Regulation by Fibrinogen and Fibrin of Streptokinase from Streptococcus Pyogenes.

ABSTRACT: Streptokinase is a virulence factor of streptococci and acts as a plasminogen activator to generate the serine protease plasmin which promotes bacterial metastasis. Streptokinase isolated from group C streptococci has been used therapeutically as a thrombolytic agent for many years and its mechanism of action has been extensively studied. However, group A streptococci are associated with invasive and potentially fatal infections, but less detail is available on the mechanism of action of streptokinase from these bacteria. We have expressed recombinant streptokinase from a group C strain to investigate the therapeutic molecule (here termed rSK-H46A) and a molecule isolated from a cluster 2a strain from group A (rSK-M1GAS) which is known to produce the fibrinogen binding, M1 protein, and is

SUBMITTER: Huish S 

PROVIDER: S-EPMC5268773 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature