Dissecting the relationship between obesity and hyperinsulinemia: Role of insulin secretion and insulin clearance.

ABSTRACT:

Objective

The aim of this study was to better delineate the complex interrelationship among insulin resistance (IR), secretion rate (ISR), and clearance rate (ICR) to increase plasma insulin concentrations in obesity.

Methods

Healthy volunteers (92 nondiabetic individuals) had an insulin suppression test to measure IR and graded-glucose infusion test to measure ISR and ICR. Obesity was defined as a body mass index (BMI) ≥30 kg/m² , and IR was defined as steady-state plasma glucose (SSPG) ≥10 mmol/L during the insulin suppression test. Plasma glucose and insulin concentrations, ISR, and ICR were compared in three groups: insulin sensitive/overweight; insulin sensitive/obesity; and insulin resistant/obesity.

Results

Compared with the insulin-sensitive/overwei

SUBMITTER: Kim MK 

PROVIDER: S-EPMC5269435 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature