A polymorphism in human MR1 is associated with mRNA expression and susceptibility to tuberculosis.

ABSTRACT: The MR1 antigen-presenting system is conserved among mammals and enables T cells to recognize small molecules produced by bacterial pathogens, including Mycobacterium tuberculosis (M.tb). However, it is not known whether MR1-mediated antigen presentation is important for protective immunity against mycobacterial disease. We hypothesized that genetic control of MR1 expression correlates with clinical outcomes of tuberculosis infection. We performed an MR1 candidate gene association study and identified an intronic single-nucleotide polymorphism (rs1052632) that was significantly associated with susceptibility to tuberculosis in a discovery and validation cohort of Vietnamese adults with tuberculosis. Stratification by site of disease revealed that rs1052632 genotype GG was strongly associat

SUBMITTER: Seshadri C 

PROVIDER: S-EPMC5269436 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature