Contraction of Blood Clots Is Impaired in Acute Ischemic Stroke.

ABSTRACT:

Objective

Obstructive thrombi or thrombotic emboli are the pathogenic basis of ischemic stroke. In vitro blood clots and in vivo thrombi can undergo platelet-driven contraction (retraction), resulting in volume shrinkage. Clot contraction can potentially reduce vessel occlusion and improve blood flow past emboli or thrombi. The aim of this work was to examine a potential pathogenic role of clot contraction in ischemic stroke.

Approach and results

We used a novel automated method that enabled us to quantify time of initiation and extent and rate of clot contraction in vitro. The main finding is that clot contraction from the blood of stroke patients was reduced compared with healthy subjects. Reduced clot contraction correlated with a lower platelet count and their dysfunctio

SUBMITTER: Tutwiler V 

PROVIDER: S-EPMC5269459 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature