Systematic Chemoenzymatic Synthesis of O-Sulfated Sialyl Lewis x Antigens.

ABSTRACT: O-Sulfated sialyl Lewis x antigens play important roles in nature. However, due to their structural complexity, they are not readily accessible by either chemical or enzymatic synthetic processes. Taking advantage of a bacterial sialyltransferase mutant that can catalyze the transfer of different sialic acid forms from the corresponding sugar nucleotide donors to Lewis x antigens which are fucosylated glycans as well as an efficient one-pot multienzyme (OPME) sialylation system, O-sulfated sialyl Lewis x antigens containing different sialic acid forms and O-sulfation at different locations were systematically synthesized by chemoenzymatic methods.

SUBMITTER: Santra A 

PROVIDER: S-EPMC5269574 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature