Primary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication.

ABSTRACT: Zika virus (ZIKV) is an emerging mosquito-borne (Aedes genus) arbovirus of the Flaviviridae family. Although ZIKV has been predominately associated with a mild or asymptomatic dengue-like disease, its appearance in the Americas has been accompanied by a multi-fold increase in reported incidence of fetal microcephaly and brain malformations. The source and mode of vertical transmission from mother to fetus is presumptively transplacental, although a causal link explaining the interval delay between maternal symptoms and observed fetal malformations following infection has been missing. In this study, we show that primary human placental trophoblasts from non-exposed donors (n = 20) can be infected by primary passage ZIKV-FLR isolate, and uniquely allowed for ZIKV viral RNA replication when

SUBMITTER: Aagaard KM 

PROVIDER: S-EPMC5269613 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature