Risk stratification of adult T-cell leukemia/lymphoma using immunophenotyping.

ABSTRACT: Adult T-cell leukemia/lymphoma (ATL), a human T-lymphotropic virus type 1 (HTLV-1)-associated disease, has a highly variable clinical course and four subtypes with therapeutic and prognostic implications. However, there are overlapping features between ATL subtypes and between ATL and nonmalignant (non-ATL) HTLV-1 infection complicating diagnosis and prognostication. To further refine the diagnosis and prognosis of ATL, we characterized the immunophenotype of HTLV-1-infected cells in ATL and non-ATL. A retrospective study of peripheral blood samples from 10 HTLV-1-uninfected subjects (UI), 54 HTLV-1-infected patients with non-ATL, and 22 with ATL was performed using flow cytometry. All patients with ATL had CD4⁺  CCR4⁺  CD26^- immunophenotype and the frequen

SUBMITTER: Kagdi HH 

PROVIDER: S-EPMC5269699 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature