An Ocular Protein Triad Can Classify Four Complex Retinal Diseases.

ABSTRACT: Retinal diseases generally are vision-threatening conditions that warrant appropriate clinical decision-making which currently solely dependents upon extensive clinical screening by specialized ophthalmologists. In the era where molecular assessment has improved dramatically, we aimed at the identification of biomarkers in 175 ocular fluids to classify four archetypical ocular conditions affecting the retina (age-related macular degeneration, idiopathic non-infectious uveitis, primary vitreoretinal lymphoma, and rhegmatogenous retinal detachment) with one single test. Unsupervised clustering of ocular proteins revealed a classification strikingly similar to the clinical phenotypes of each disease group studied. We developed and independently validated a parsimonious model based merely on t

SUBMITTER: Kuiper JJ 

PROVIDER: S-EPMC5269719 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature