Assessing in silico the recruitment and functional spectrum of bacterial enzymes from secondary metabolism.

ABSTRACT:

Background

Microbes, plants, and fungi synthesize an enormous number of metabolites exhibiting rich chemical diversity. For a high-level classification, metabolism is subdivided into primary (PM) and secondary (SM) metabolism. SM products are often not essential for survival of the organism and it is generally assumed that SM enzymes stem from PM homologs.

Results

We wanted to assess evolutionary relationships and function of bona fide bacterial PM and SM enzymes. Thus, we analyzed the content of 1010 biosynthetic gene clusters (BGCs) from the MIBiG dataset; the encoded bacterial enzymes served as representatives of SM. The content of 15 bacterial genomes known not to harbor BGCs served as a representation of PM. Enzymes were categorized on their EC number and for these enzy

SUBMITTER: Veprinskiy V 

PROVIDER: S-EPMC5270213 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature