An Oxidoreductase AioE is Responsible for Bacterial Arsenite Oxidation and Resistance.

ABSTRACT: Previously, we found that arsenite (As^III) oxidation could improve the generation of ATP/NADH to support the growth of Agrobacterium tumefaciens GW4. In this study, we found that aioE is induced by As^III and located in the arsenic island near the As^III oxidase genes aioBA and co-transcripted with the arsenic resistant genes arsR1-arsC1-arsC2-acr3-1. AioE belongs to TrkA family corresponding the electron transport function with the generation of NADH and H⁺. An aioE in-frame deletion strain showed a null As^III oxidation and a reduced As^III resistance, while a cytC mutant only reduced As^III oxidation efficiency. With As^III, aioE was directly related to the increase of NADH, while cytC was essential for AT

SUBMITTER: Wang Q 

PROVIDER: S-EPMC5270249 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature