Template-based intervention in Boolean network models of biological systems.

ABSTRACT:

Motivation

A grand challenge in the modeling of biological systems is the identification of key variables which can act as targets for intervention. Boolean networks are among the simplest of models, yet they have been shown to adequately model many of the complex dynamics of biological systems. In our recent work, we utilized a logic minimization approach to identify quality single variable targets for intervention from the state space of a Boolean network. However, as the number of variables in a network increases, the more likely it is that a successful intervention strategy will require multiple variables. Thus, for larger networks, such an approach is required in order to identify more complex intervention strategies while working within the limited view of the network's state

SUBMITTER: Verdicchio MP 

PROVIDER: S-EPMC5270454 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature