The GS Protein-coupled A2a Adenosine Receptor Controls T Cell Help in the Germinal Center.

ABSTRACT: T follicular helper (T_FH) cells have been shown to be critically required for the germinal center (GC) reaction where B cells undergo class switch recombination and clonal selection to generate high affinity neutralizing antibodies. However, detailed knowledge of the physiological cues within the GC microenvironment that regulate T cell help is limited. The cAMP-elevating, G_s protein-coupled A2a adenosine receptor (A2aR) is an evolutionarily conserved receptor that limits and redirects cellular immunity. However, the role of A2aR in humoral immunity and B cell differentiation is unknown. We hypothesized that the hypoxic microenvironment within the GC facilitates an extracellular adenosine-rich milieu, which serves to limit T_FH frequency and function, and al

SUBMITTER: Abbott RK 

PROVIDER: S-EPMC5270467 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature