The secretome of MUSE cells contains factors that may play a role in regulation of stemness, apoptosis and immunomodulation.

ABSTRACT: Mesenchymal stromal cells (MSCs) are a heterogeneous population, which contain several cell phenotypes: mesenchymal stem cells, progenitor cells, fibroblasts and other type of cells. Previously, we identified unique stem cells that we named multilineage-differentiating stress enduring (Muse) cells as one to several percent of MSCs of the bone marrow, adipose tissue and dermis. Among different cell populations in MSCs, Muse cells, positive for pluripotent surface marker SSEA-3, may represent cells responsible for pluripotent-like property of MSCs, since they express pluripotency genes, able to differentiated into triploblastic cells from a single cells and are self-renewable. MSCs release biologically active factors that have profound effects on local cellular dynamics. A thorough examinati

SUBMITTER: Alessio N 

PROVIDER: S-EPMC5270533 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature