Antibiotic resistance potential of the healthy preterm infant gut microbiome.

ABSTRACT:

Background

Few studies have investigated the gut microbiome of infants, fewer still preterm infants. In this study we sought to quantify and interrogate the resistome within a cohort of premature infants using shotgun metagenomic sequencing. We describe the gut microbiomes from preterm but healthy infants, characterising the taxonomic diversity identified and frequency of antibiotic resistance genes detected.

Results

Dominant clinically important species identified within the microbiomes included C. perfringens, K. pneumoniae and members of the Staphylococci and Enterobacter genera. Screening at the gene level we identified an average of 13 antimicrobial resistance genes per preterm infant, ranging across eight different antibiotic classes, includ

SUBMITTER: Rose G 

PROVIDER: S-EPMC5270596 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature