Understanding the Impact of Stroke on Brain Motor Function: A Hierarchical Bayesian Approach.

ABSTRACT: Stroke is a disturbance in blood supply to the brain resulting in the loss of brain functions, particularly motor function. A study was conducted by the UCI Neurorehabilitation Lab to investigate the impact of stroke on motor-related brain regions. Functional MRI (fMRI) data were collected from stroke patients and healthy controls while the subjects performed a simple motor task. In addition to affecting local neuronal activation strength, stroke might also alter communications (i.e., connectivity) between brain regions. We develop a hierarchical Bayesian modeling approach for the analysis of multi-subject fMRI data that allows us to explore brain changes due to stroke. Our approach simultaneously estimates activation and condition-specific connectivity at the group level, and provides est

SUBMITTER: Yu Z 

PROVIDER: S-EPMC5270649 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature