Slm35 links mitochondrial stress response and longevity through TOR signaling pathway.

ABSTRACT: In most eukaryotic cells mitochondria are essential organelles involved in a great variety of cellular functions. One of the physiological processes linked to mitochondria is aging, a gradual process of damage accumulation that eventually promotes cell death. Aging depends on a balance between mitochondrial biogenesis, function and degradation. It has been previously shown that Tor1, Sch9 and Ras2 are activated in response to nutrient availability and regulate cell growth and division. A deficiency in any of these genes promotes lifespan extension and cell protection during oxidative and heat shock stress. In this work we report that in Saccharomyces cerevisiae, the uncharacterized mitochondrial protein Slm35 is functionally linked with the TOR signaling pathway. A Δtor1Δs

SUBMITTER: Aguilar-Lopez JL 

PROVIDER: S-EPMC5270667 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature