Plasma HIV-1 Tropism and the Risk of Short-Term Clinical Progression to AIDS or Death.

ABSTRACT:

Objective

To investigate if plasma HIV-1 tropism testing could identify subjects at higher risk for clinical progression and death in routine clinical management.

Design

Nested case-control study within the EuroSIDA cohort.

Methods

Cases were subjects with AIDS or who died from any cause, with a plasma sample with HIV-1 RNA >1000 copies/mL available for tropism testing 3 to 12 months prior to the event. At least 1 control matched for age, HIV-1 RNA and HCV status at the time of sampling were selected per each case. Conditional logistic regression was used to investigate exposures associated with clinical progression to AIDS or death. A linear mixed model with random intercept was used to compare CD4+T-cell slopes by HIV tropism over the 12 months following the date of

SUBMITTER: Casadella M 

PROVIDER: S-EPMC5271314 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature