Investigations into Retinal Pathology in the Early Stages of a Mouse Model of Alzheimer's Disease.

ABSTRACT: There is increasing recognition that visual performance is impaired in early stages of Alzheimer's disease (AD); however, no consensus exists as to the mechanisms underlying this visual dysfunction, in particular regarding the timing, nature, and extent of retinal versus cortical pathology. If retinal pathology presents sufficiently early, it offers great potential as a source of novel biomarkers for disease diagnosis. The current project utilized an array of immunochemical and molecular tools to perform a characterization of retinal pathology in the early stages of disease progression using a well-validated mouse model of AD (APPSWE/PS1ΔE9). Analytical endpoints included examination of aberrant amyloid and tau in the retina, quantification of any neuronal degeneration, delineation of cell

SUBMITTER: Chidlow G 

PROVIDER: S-EPMC5271427 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature