Preliminary Evaluation of Clinician Rated Outcome Measures in Mitochondrial Disease.

ABSTRACT:

Background

Currently there are no known cures and few effective treatments for mitochondrial disorders. It is also true there is a lack of knowledge about suitable clinician rated outcomes and how these change over time in this patient cohort.

Objective

We sought to evaluate the validity and responsiveness to change of clinician rated outcome measures in patients with m.3243A>G-related mitochondrial disease.

Methods

We assessed the six minute timed walk (6MTW), 10 meter walk / test (10MWT), Timed up and Go (TUG) and the 5 times sit to stand (5XSTS), in 18 patients (12 sedentary controls), at baseline and a subgroup of 10 control-matched patients following a 16-week structured aerobic exercise intervention program.

Results

All outcome measures assessed were vali

SUBMITTER: Newman J 

PROVIDER: S-EPMC5271457 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature