Ten Years of Proteomics in Bladder Cancer: Progress and Future Directions.

ABSTRACT: Research efforts targeting the identification of bladder cancer biomarkers have been extensive during the past decade. Investigations have been performed at the genome, transcriptome, proteome, and metabolome levels and outputs have started appearing including the sketching of disease molecular subtypes. Proteins are directly linked to cell phenotype hence they accumulate special interest as both biomarkers and therapeutic targets. Multiple technical challenges exist, of the main, being the protein concentration vast dynamic range and presence of proteins in modified forms. The scope of this review is to summarize the contribution of proteomics research in this quest of bladder cancer biomarkers. To obtain an unbiased and comprehensive overview, the scientific literature was searched for m

SUBMITTER: Frantzi M 

PROVIDER: S-EPMC5271479 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature