The Brain in Kidney Disease (BRINK) Cohort Study: Design and Baseline Cognitive Function.

ABSTRACT:

Background

The Brain in Kidney Disease (BRINK) Study aims to identify mechanisms that contribute to increased risk for cognitive impairment in patients with chronic kidney disease (CKD). We describe the rationale, design, and methods of the study and report baseline recruitment and cognitive function results.

Study design

Longitudinal observational cohort study of the epidemiology of cognitive impairment in CKD. The primary aim is to characterize the association between (1) baseline and incident stroke, white matter disease, estimated glomerular filtration rate (eGFR), inflammation, microalbuminuria, and dialysis initiation and (2) cognitive decline over 3 years in a CKD cohort with a mean eGFR<45 mL/min/1.73 m(2).

Setting & participants

Community-dwelling participant

SUBMITTER: Murray AM 

PROVIDER: S-EPMC5271565 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature