"Get the Balance Right": Pathological Significance of Autophagy Perturbation in Neuromuscular Disorders.

ABSTRACT: Recent research has revealed that autophagy, a major catabolic process in cells, is dysregulated in several neuromuscular diseases and contributes to the muscle wasting caused by non-muscle disorders (e.g. cancer cachexia) or during aging (i.e. sarcopenia). From there, the idea arose to interfere with autophagy or manipulate its regulatory signalling to help restore muscle homeostasis and attenuate disease progression. The major difficulty for the development of therapeutic strategies is to restore a balanced autophagic flux, due to the dynamic nature of autophagy. Thus, it is essential to better understand the mechanisms and identify the signalling pathways at play in the control of autophagy in skeletal muscle. A comprehensive analysis of the autophagic flux and of the causes of its dysr

SUBMITTER: Castets P 

PROVIDER: S-EPMC5271579 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature