Impulsivity and aggression mediate regional brain responses in Borderline Personality Disorder: An fMRI study.

ABSTRACT: Fronto-limbic brain networks involved in regulation of impulsivity and aggression are abnormal in Borderline Personality Disorder (BPD). However, it is unclear whether, or to what extent, these personality traits actually modulate brain responses during cognitive processing. Using fMRI, we examined the effects of trait impulsivity, aggression, and depressed mood on regional brain responses in 31 female BPD and 25 control subjects during a Go No-Go task using Ekman faces as targets. First-level contrasts modeled effects of negative emotional context. Second-level regression models used trait impulsivity, aggression and depressed mood as predictor variables of regional brain activations. In BPD, trait impulsivity was positively correlated with activation in the dorsal anterior cingulate cort

SUBMITTER: Soloff PH 

PROVIDER: S-EPMC5272782 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature