Risk of malignant childhood germ cell tumors in relation to demographic, gestational, and perinatal characteristics.

ABSTRACT:

Background

Childhood germ cell tumors (GCTs) are a rare assortment of neoplasms, with mostly unknown etiology, that are believed to originate very early in life. Few studies have examined risk factors by histologic subtype, despite evidence of different risk profiles.

Materials and methods

In this population-based case-control study, 451 childhood malignant GCT cases ages 0-5 years were identified from the California Cancer Registry. Differentiating between common histologic subtypes, we identified 181 yolk sac tumors, 216 teratomas, and 54 rarer subtypes. Cases were linked to their birth certificates and 271,381 controls, frequency matched by birth year, were randomly selected from California birthrolls to investigate the contributions of demographic, gestational, and pregn

SUBMITTER: Hall C 

PROVIDER: S-EPMC5272784 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature