Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB.

ABSTRACT:

Objective

To conduct a validation study of ¹²³I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (¹²³I-FP-CIT) SPECT dopaminergic imaging in the clinical diagnosis of dementia with Lewy bodies (DLB) with autopsy as the gold standard.

Methods

Patients >60 years of age with dementia who had undergone ¹²³I-FP-CIT imaging in research studies and who had donated their brain tissue to the Newcastle Brain Tissue Resource were included. All had structured clinical research assessments, and clinical diagnoses were applied by consensus panels using international diagnostic criteria. All underwent ¹²³I-FP-CIT imaging at baseline, and scans were rated as normal or abnormal by blinded raters. Patients were reviewed in prospective stu

SUBMITTER: Thomas AJ 

PROVIDER: S-EPMC5272795 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature