Modulation of excitation on parvalbumin interneurons by neuroligin-3 regulates the hippocampal network.

ABSTRACT: Hippocampal network activity is generated by a complex interplay between excitatory pyramidal cells and inhibitory interneurons. Although much is known about the molecular properties of excitatory synapses on pyramidal cells, comparatively little is known about excitatory synapses on interneurons. Here we show that conditional deletion of the postsynaptic cell adhesion molecule neuroligin-3 in parvalbumin interneurons causes a decrease in NMDA-receptor-mediated postsynaptic currents and an increase in presynaptic glutamate release probability by selectively impairing the inhibition of glutamate release by presynaptic Group III metabotropic glutamate receptors. As a result, the neuroligin-3 deletion altered network activity by reducing gamma oscillations and sharp wave ripples, changes asso

SUBMITTER: Polepalli JS 

PROVIDER: S-EPMC5272845 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature