Chronic peripheral nerve compression disrupts paranodal axoglial junctions.

ABSTRACT:

Introduction

Peripheral nerves are often exposed to mechanical stress leading to compression neuropathies. The pathophysiology underlying nerve dysfunction by chronic compression is largely unknown.

Methods

We analyzed molecular organization and fine structures at and near nodes of Ranvier in a compression neuropathy model in which a silastic tube was placed around the mouse sciatic nerve.

Results

Immunofluorescence study showed that clusters of cell adhesion complex forming paranodal axoglial junctions were dispersed and overlapped frequently with juxtaparanodal components. These paranodal changes occurred without internodal myelin damage. The distribution and pattern of paranodal disruption suggests that these changes are the direct result of mechanical stress. Elec

SUBMITTER: Otani Y 

PROVIDER: S-EPMC5272873 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature