Genome-Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians.

ABSTRACT:

Objective

A major barrier to genetic studies of osteoarthritis (OA) is the need to obtain large numbers of individuals with standardized radiographic evaluations for OA. To address this gap, we performed a genome-wide association study (GWAS) of radiographically defined tibiofemoral knee OA in 3,898 cases and 3,168 controls from 4 well-characterized North American cohorts, and we performed replication analysis of previously reported OA loci.

Methods

We performed meta-analysis using a 2-stage design. Stage 1 (discovery) consisted of a GWAS meta-analysis of radiographic knee OA carried out in the Osteoarthritis Initiative and the Johnston County Osteoarthritis Project. Knee OA was defined as definite osteophytes and possible joint space narrowing or total joint replacement in

SUBMITTER: Yau MS 

PROVIDER: S-EPMC5274579 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature