White Matter Volume Predicts Language Development in Congenital Heart Disease.

ABSTRACT:

Objective

To determine whether brain volume is reduced at 1 year of age and whether these volumes are associated with neurodevelopment in biventricular congenital heart disease (CHD) repaired in infancy.

Study design

Infants with biventricular CHD (n = 48) underwent brain magnetic resonance imaging (MRI) and neurodevelopmental testing with the Bayley Scales of Infant Development-II and the MacArthur-Bates Communicative Development Inventories at 1 year of age. A multitemplate based probabilistic segmentation algorithm was applied to volumetric MRI data. We compared volumes with those of 13 healthy control infants of comparable ages. In the group with CHD, we measured Spearman correlations between neurodevelopmental outcomes and the residuals from linear regression of the vol

SUBMITTER: Rollins CK 

PROVIDER: S-EPMC5274582 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature