Abnormal structural and functional hypothalamic connectivity in mild traumatic brain injury.

ABSTRACT:

Purpose

To investigate whether there is imaging evidence of hypothalamic injury in patients with mild traumatic brain injury (MTBI), which is a major public health problem due to the high prevalence and difficulty in diagnosis and treatment.

Materials and methods

Twenty-four patients (mean age 34.2, range, 18-56 years) with symptomatic MTBI and 22 age-matched healthy controls (mean age 37.0, range 20-61 years) participated in the study. Diffusion kurtosis imaging was performed with diffusion-weighted images acquired along 30 gradient directions and three b-values (b = 0, 1000, 2000 s/mm² ) based on a twice-refocused spin-echo sequence with a 3T magnetic resonance imaging (MRI) scanner. Resting-state functional (f)MRI with standard echo planar imaging (EPI) were pe

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC5274605 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature