Ontology highlight
ABSTRACT:
SUBMITTER: Van Dyken SJ
PROVIDER: S-EPMC5275767 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Nature immunology 20161017 12
Group 2 innate lymphoid cells (ILC2s) and CD4<sup>+</sup> type 2 helper T cells (T<sub>H</sub>2 cells) are defined by their similar effector cytokines, which together mediate the features of allergic immunity. We found that tissue ILC2s and T<sub>H</sub>2 cells differentiated independently but shared overlapping effector function programs that were mediated by exposure to the tissue-derived cytokines interleukin 25 (IL-25), IL-33 and thymic stromal lymphopoietin (TSLP). Loss of these three tissu ...[more]