Focal temporal pole atrophy and network degeneration in semantic variant primary progressive aphasia.

ABSTRACT: A wealth of neuroimaging research has associated semantic variant primary progressive aphasia with distributed cortical atrophy that is most prominent in the left anterior temporal cortex; however, there is little consensus regarding which region within the anterior temporal cortex is most prominently damaged, which may indicate the putative origin of neurodegeneration. In this study, we localized the most prominent and consistent region of atrophy in semantic variant primary progressive aphasia using cortical thickness analysis in two independent patient samples (n = 16 and 28, respectively) relative to age-matched controls (n = 30). Across both samples the point of maximal atrophy was located in the same region of the left temporal pole. This same region was the point of maximal atrophy

SUBMITTER: Collins JA 

PROVIDER: S-EPMC5278308 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature