Computational modelling of traumatic brain injury predicts the location of chronic traumatic encephalopathy pathology.

ABSTRACT: Traumatic brain injury can lead to the neurodegenerative disease chronic traumatic encephalopathy. This condition has a clear neuropathological definition but the relationship between the initial head impact and the pattern of progressive brain pathology is poorly understood. We test the hypothesis that mechanical strain and strain rate are greatest in sulci, where neuropathology is prominently seen in chronic traumatic encephalopathy, and whether human neuroimaging observations converge with computational predictions. Three distinct types of injury were simulated. Chronic traumatic encephalopathy can occur after sporting injuries, so we studied a helmet-to-helmet impact in an American football game. In addition, we investigated an occipital head impact due to a fall from ground level and

SUBMITTER: Ghajari M 

PROVIDER: S-EPMC5278309 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature