CD133⁺ cancer stem cells promoted by VEGF accelerate the recurrence of hepatocellular carcinoma.

ABSTRACT: The role of cancer stem cells (CSCs) in inducing the recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) remains unclear. Here, we found that a dramatic increase in plasma vascular endothelial growth factor (VEGF) and an induction of local CD133⁺ CSCs are associated with early HCC recurrence, suggesting that VEGF expression and tumour stemness contribute to the relapse. In vitro studies demonstrated that VEGF, via activation of VEGFR2, increased the number of CD133⁺ CSCs and enhanced their capacity for self-renewal by inducing the expression of Nanog. In vivo studies further demonstrated that VEGF-treated CD133⁺ CSCs formed tumours larger than those developing from unstimulated cells and VEGF pre-treatment increased the tumorige

SUBMITTER: Liu K 

PROVIDER: S-EPMC5278354 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature