Bacterial translocation aggravates CCl₄-induced liver cirrhosis by regulating CD4⁺ T cells in rats.

ABSTRACT: Bacterial translocation (BT) is thought to play an important role in the development of liver cirrhosis, but the mechanisms have not been fully explored. This study aims to investigate the distribution of Treg (CD3⁺CD4⁺CD25⁺Foxp3⁺), Th17 (CD3⁺CD4⁺IL-17⁺), and Th1 (CD3⁺CD4⁺IFN-γ⁺) cells in the intestinal lamina propria, liver and blood and to explore their relationships with BT. Cirrhotic rats with ascites were induced by CCl₄. We found that there were lower levels of total protein and albumin, lower albumin/globulin ratio, lower body weight and higher spleen weight and ascites volume in cirrhotic rats with than without BT. We found that BT may cause increase of Treg cell

SUBMITTER: Shi H 

PROVIDER: S-EPMC5278361 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature