A comprehensive analysis of the germline and expressed TCR repertoire in White Peking duck.

ABSTRACT: Recently, many immune-related genes have been extensively studied in ducks, but relatively little is known about their TCR genes. Here, we determined the germline and expressed repertoire of TCR genes in White Peking duck. The genomic organization of the duck TCRα/δ, TCRγ and unconventional TCRδ2 loci are highly conserved with their counterparts in mammals or chickens. By contrast, the duck TCRβ locus is organized in an unusual pattern, (Vβ)_n-Dβ-(Jβ)₂-Cβ1-(Jβ)₄-Cβ2, which differs from the tandem-aligned clusters in mammals or the translocon organization in some teleosts. Excluding the first exon encoding the immunoglobulin domain, the subsequent exons of the two Cβ show significant diversity in nucleotide sequence and exon structure. Based on the nucleotide

SUBMITTER: Yang Z 

PROVIDER: S-EPMC5278385 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature