Basophil-derived IL-6 regulates T_H17 cell differentiation and CD4 T cell immunity.

ABSTRACT: Basophils are rare, circulating granulocytes proposed to be involved in T helper (T_H) type 2 immunity, mainly through secretion of interleukin (IL)-4. In addition to IL-4, basophils produce IL-6 and tumor necrosis factor (TNF)-α in response to immunoglobulin E (IgE) crosslinking. Differentiation of T_H17 cells requires IL-6 and transforming growth factor (TGF)-β, but whether basophils play a significant role in T_H17 induction is unknown. Here we show a role for basophils in T_H17 cell development by using in vitro T cell differentiation and in vivo T_H17-mediated inflammation models. Bone marrow derived-basophils (BMBs) and splenic basophils produce significant amounts of IL-6 as well as IL-4 following stimulation with IgE crosslink or ch

SUBMITTER: Yuk CM 

PROVIDER: S-EPMC5278410 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature