Candida albicans stimulates Streptococcus mutans microcolony development via cross-kingdom biofilm-derived metabolites.

ABSTRACT: Candida albicans is frequently detected with heavy infection of Streptococcus mutans in plaque-biofilms from children affected with early-childhood caries, a prevalent and costly oral disease. The presence of C. albicans enhances S. mutans growth within biofilms, yet the chemical interactions associated with bacterial accumulation remain unclear. Thus, this study was conducted to investigate how microbial products from this cross-kingdom association modulate S. mutans build-up in biofilms. Our data revealed that bacterial-fungal derived conditioned medium (BF-CM) significantly increased the growth of S. mutans and altered biofilm 3D-architecture in a dose-dependent manner, resulting in enlarged and densely packed bacterial cell-clusters (microcolonies). Intriguingly, BF-CM induced S. mutan

SUBMITTER: Kim D 

PROVIDER: S-EPMC5278416 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature