Does von Willebrand factor improve the predictive ability of current risk stratification scores in patients with atrial fibrillation?

ABSTRACT: Von Willebrand factor (vWF) is a biomarker of endothelial dysfunction. We investigated its role on prognosis in anticoagulated atrial fibrillation (AF) patients and determined whether its addition to clinical risk stratification schemes improved event-risk prediction. Consecutive outpatients with non-valvular AF were recruited and rates of thrombotic/cardiovascular events, major bleeding and mortality were recorded. The effect of vWF on prognosis was calculated using a Cox regression model. Improvements in predictive accuracy over current scores were determined by calculating the integrated discrimination improvement (IDI), net reclassification improvement (NRI), comparison of receiver-operator characteristic (ROC) curves and Decision Curve Analysis (DCA). 1215 patients (49% males, age 76

SUBMITTER: Garcia-Fernandez A 

PROVIDER: S-EPMC5278507 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature