Associations of triglyceride levels with longevity and frailty: A Mendelian randomization analysis.

ABSTRACT: Observational studies suggest associations of triglyceride levels with longevity and frailty. This study aimed to test whether the associations are causal. We used data from the Rugao Longevity and Ageing Study, a population-based cohort study performed in Rugao, China. A variant in the APOA5 gene region (rs662799) was used as the genetic instrument. Mendelian randomization (MR) analyses were performed to examine the associations of genetically predicted triglycerides with two ageing phenotypes - longevity ( ≥95 years) and frailty (modified Fried frailty phenotype and Rockwood frailty index). C allele of rs662799 was robustly associated with higher triglyceride levels in the comparison group (β = 0.301 mmol/L per allele, p < 0.001), with an F statistic of 95.3 and R² = 0.040. Ho

SUBMITTER: Liu Z 

PROVIDER: S-EPMC5278549 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature