Genetically defined race, but not sex, is associated with higher humoral and cellular immune responses to measles vaccination.

ABSTRACT: In addition to host genetic and environmental factors, variations in immune responses to vaccination are influenced by demographic variables, such as race and sex. The influence of genetic race and sex on measles vaccine responses is not well understood, yet important for the development of much-needed improved measles vaccines with lower failure rates. We assessed associations between genetically defined race and sex with measles humoral and cellular immunity after measles vaccination in three independent and geographically distinct cohorts totaling 2872 healthy racially diverse children, older adolescents, and young adults. We found no associations between biological sex and either humoral or cellular immunity to measles vaccine, and no correlation between humoral and cellular immunity i

SUBMITTER: Voigt EA 

PROVIDER: S-EPMC5278779 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature