Methylphenidate, cognition, and epilepsy: A double-blind, placebo-controlled, single-dose study.

ABSTRACT:

Objective

To evaluate the potential efficacy of immediate-release methylphenidate (MPH) for treating cognitive deficits in epilepsy.

Methods

This was a double-blind, randomized, single-dose, 3-period crossover study in patients with epilepsy and chronic cognitive complaints comparing the effects of placebo and MPH 10 and 20 mg given 1 week apart. Cognitive outcome was evaluated on the basis of an omnibus z score calculated from performance on the Conners Continuous Performance Test 3 (ability to discriminate between target and nontarget stimuli [d'] and hit reaction time standard deviation), Symbol-Digit Modalities Test, and Medical College of Georgia Paragraph Memory Test. Adverse events and seizure frequency were monitored. An open-label follow-up is reported elsewhere.

SUBMITTER: Adams J 

PROVIDER: S-EPMC5278946 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature