Multicenter stability of resting state fMRI in the detection of Alzheimer's disease and amnestic MCI.

ABSTRACT:

Background

In monocentric studies, patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia exhibited alterations of functional cortical connectivity in resting-state functional MRI (rs-fMRI) analyses. Multicenter studies provide access to large sample sizes, but rs-fMRI may be particularly sensitive to multiscanner effects.

Methods

We used data from five centers of the "German resting-state initiative for diagnostic biomarkers" (psymri.org), comprising 367 cases, including AD patients, MCI patients and healthy older controls, to assess the influence of the distributed acquisition on the group effects. We calculated accuracy of group discrimination based on whole brain functional connectivity of the posterior cingulate cortex (PCC) using pooled sam

SUBMITTER: Teipel SJ 

PROVIDER: S-EPMC5279697 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature